Fall 2021

NURS 6338-001 Advanced Pathophysiology

All students are responsible for checking their UTHSCSA Livemail account regularly (i.e., daily or several times every week) to obtain Official University Communication regarding their courses, program and student status.

Students are expected to follow all policies related to COVID-19 found on the university webpage: https://wp.uthscsa.edu/coronavirus/.

NOTE: Our campus has enabled the CANVAS MOBILE LEARN application. CANVAS tools such as discussions, quizzes or videos May or May NOT function on all mobile devices. This is because mobile devices are available with rapidly changing and different configurations. Hence, students must not depend on only a mobile device to access course materials. Students must have access to a laptop or desktop device to access course materials and complete assignments.

This course is Web Enhanced with WebCT icon
Please be sure to check the Current Computer Requirements

  Dr. Raabe and I would like to welcome you to NURS 6338 (01)

  Advanced Pathophysiology.  


  We look forward to a successful semester, and please do not
  hesitate to contact us with any questions or concerns.

  Nancy McGowan, RN, PhD, CEN


Nancy McGowan, RN, PhD, CEN
Associate Professor/Clinical
Email:  McGowann@uthscsa.edu
Office phone:  (210) 567-5310
Office : 2.222 (School of Nursing)

Timothy Raabe, PhD
Professor, School of Nursing
Associate Dean, Graduate School of Biomedical Sciences
Email:  Raabe@uthscsa.edu
Office phone:  (210) 567-3714
Office:  AAB 1.104


In this course students focus on advanced pathophysiological processes across the lifespan, incorporating use of clinical reasoning skills to distinguish alterations across multiple physiological systems.


Credit Hour Allocation: 3 Semester Credit Hours
Clock Hour Allocation: 3 Clock Hours Class (45 hours class)


Graduate standing


Upon completion of the Doctor of Nursing Practice (DNP) Program students will:

  1. Integrate nursing science, ethics, biophysical, psychosocial, analytical, and organizational sources to provide the highest level of specialty nursing practices.
  2. Develop, implement, and evaluate healthcare practices in healthcare systems that ensure quality improvement and patient safety.
  3. Use analytic methods and evidence based practices to improve practice outcomes and the practice environment.
  4. Implement and evaluate ethical healthcare information systems and patient care technology to improve the quality of patient health outcomes and care systems.
  5. Advocate for healthcare practices that advance social justice, equity, and ethical policies within all healthcare arenas.
  6. Employ interprofessional collaborative teams to improve patient and population health outcomes and healthcare delivery systems.
  7. Lead the integration and institutionalization of (evidence based) clinical prevention and population based health guidelines.
  8. Use clinical judgment, systems thinking, accountability, and specialized knowledge to design, deliver, and evaluate evidence based, culturally proficient care to improve patient, population, and health systems outcomes.


Course Objectives
1.  Analyze epigenomics, physiological alterations and pathophysiological processes of disorders and diseases as manifested across the lifespan. (DNP Essentials I, IV, VII, VIII; NONPF Competencies: Scientific Foundation 1, 2, Quality 1)
2.  Integrate current scientific findings into problem-based analysis of disorders and disease manifested across the lifespan. (DNP Essentials I, III, IV, VIII; NONPF Competency: Scientific Foundation 1, 2)
3.  Differentiate among diagnostic studies that evaluate and discriminate pathophysiological processes. (DNP Essentials I, IV, VIII; NONPF Competencies: Scientific Foundation 1, 2, Quality 1, 2)
4.  Apply clinical reasoning skills and knowledge of pathophysiological processes to advanced nursing practice. (DNP Essentials I, III, IV, VIII; NONPF Competencies: Scientific Foundation 1, 2, Independent Practice 1, 2, 3, 4)




A = 4 points (90-100)
B = 3 points (80-89)
C = 2 points (75-79)
D = 1 point (66-74)
F = 0 points (65 or below)


NURS 6338 is unique in that the grade you receive will be based on a "point" system.  The points are achieved through a variety of methods.  The class will use a system from Elsevier called "Sherpath".   Quizzes, lessons and extra-credit assignments are all available through this system.  

We will go into detail regarding the grading, and the point system on the first day of class.  Students have found this to be a helpful way of completing the course, and achieving their goals.


Attendance in class is an expectation of each student.


  1. If written assignments are made in a course they are required.
  2. Students are expected to submit written work on the scheduled date and time.
  3. The student must notify the course coordinator prior to the scheduled due date and time if they are unable to submit the written work as scheduled. Failure to make this notification in advance will result in a "zero" for that written work.
  4. If the excuse is accepted as reasonable and necessary, arrangements will be made for an alternative due date and time.
  5. Each student is responsible for making sure that he or she has completed the written work prior to submission.
  6. Late work will be accepted with consequences as outlined per course syllabi.


The APA Publication Manual 7th edition is required for use in all nursing school programs. 


Students are expected to be above reproach in all scholastic activities. Students who engage in scholastic dishonesty are subject to disciplinary penalties, including the possibility of failure in the course and dismissal from the university. "Scholastic dishonesty includes but is not limited to cheating, plagiarism, collusion, and submission for credit of any work or materials that are attributable in whole or in part to another person, taking an examination for another person, any act designed to give unfair advantage to a student or the attempt to commit such acts." Regents Rules and Regulations, Part One, Chapter VI, Section 3, Subsection 3.2, Subdivision 3.22.


Students who are nurses or are preparing to enter the profession of nursing are expected to treat others with respect and compassion. “The principle of respect for persons extends to all individuals with whom the nurse interacts. The nurse maintains compassionate and caring relationships with colleagues and others with a commitment to the fair treatment of individuals, to integrity-preserving compromise and to resolving conflict. This standard of conduct precludes any and all prejudicial actions, any form of harassment or threatening behavior, or disregard for the effects of one’s actions on others” (American Nurses Association Code for Nurses, Interpretive Statement 1.5).

The students, faculty, Department Chairs, Associate Deans, and the Dean of the School of Nursing of the University Texas Health Science Center San Antonio subscribe to the highest standards of conduct. Our aim is professional behavior beyond reproach. Failure to abide by the signed code of professional conduct may lead to suspension and/or permanent dismissal from the UTHSCSA SON. In particular, we subscribe to the provisions of the Code of Ethics for Nurses (http://bit.ly/1mtD5p2) and the following points of conduct.


School of Nursing Netiquette Guidelines for Online Interaction

Netiquette guidelines provide information for behaving properly online, when using email, tweets or texts so that you may successfully communicate your thoughts in a manner that is respectful and avoids misunderstandings with others.


Any student seeking reasonable accommodations through the Americans with Disabilities Act (ADA) should contact either the Associate Dean for Admissions and Student Services within the first week of the semester or schedule a meeting with the UTHSCSA ADA Compliance Office so that appropriate accommodations may be arranged. A request for accommodations (Form ADA-100: http://uthscsa.edu/eeo/form100-Faculty-student-resident.pdf) must be completed and submitted to the Executive Director of the ADA Compliance Office before accommodations can be provided. Additional information can be provided in the Student Success Center, Room 1.118 or through the ADA Compliance Office website: http://uthscsa.edu/eeo/request.asp.


The required book is the Sherpath Electronic Package.  The ISBN is:  9780323743495.  This will contain the access code and material you will need to access the course.
Please make sure that you buy this e-book from the UTHSCSA bookstore.  You will be provided with an access code for the book that will be used.  This access code will allow access to the "Sherpath" component of the course.



McCance, K.L. & Huether, S.E. (2019).  Pathophysiology: the biologic basis for disease in adults and children (8th ed.)  Study Guide.  St. Louis: Elsevier.

ISBN:  978-0-323-41309-1

This is a paperback study guide with a number of helpful resources.


Advanced Pathophysiology across the life span is analyzed in the following processes:

1.            Cellular and epigenomic alterations, adaptation, malignancy and death

2.            Immune function alterations

3.            Integument and tissue repair alterations

4.            Hematological function alterations

5.            Neurologic function alterations

6.            Endocrine function alterations

7.            Reproductive function alterations

8.            Cardiovascular function alterations

9.            Pulmonary function alterations

10.        Renal function alterations

11.        Gastrointestinal tract and related body systems functionalterations

12.        Musculoskeletal function alterations

13.        Multi-system function alterations

CALENDAR - 1st Day Only

Please check the schedule for recent updates on Class Dates & Room.

All the requirements of the course, along with the course calendar will be discussed on the first day of class.

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