Fall 2010

NURS 5338-01 Advanced Pathophysiology

All students are responsible for checking their UTHSCSA Livemail account regularly (i.e., daily or several times every week) to obtain Official University Communication regarding their courses, program and student status.

NOTE: Our campus has enabled the CANVAS MOBILE LEARN application. CANVAS tools such as discussions, quizzes or videos May or May NOT function on all mobile devices. This is because mobile devices are available with rapidly changing and different configurations. Hence, students must not depend on only a mobile device to access course materials. Students must have access to a laptop or desktop device to access course materials and complete assignments.

This course is Web Enhanced with WebCT icon
Please be sure to check the Current Computer Requirements

Link to Graduate Clinical Experiences and Project Concert guides: http://nursing.uthscsa.edu/gradclinical/

Course packet may be access through Blackboard's Main Content page.  Additional materials will be emailed or distributed in class on or before Thursday, August 26, 2010.


Gordon, Phyllis, MSN, RN, ACNS-BC
E-mail: gordonp@uthscsa.edu
Nursing School Office Phone: (210) 567-5895 (Thu & Fri)
Clinic Office Phone:  (210) 567-6882 (M, T, W)
Office Fax: (210) 567-1719 (NS) or 567-1762 (Clinic)
Cell Phone: (210) 834-2692
Pager: (210) 203-7420
Office Room: NS 2.218
Office Hours: Thu 1:00 – 4:00pm
Health Restoration and Care Systems Management Nursing Care Department

Jackson, Brenda, PhD, RN
E-mail: jacksonbg@uthscsa.edu
Office Phone: (210) 567-1987
Office Fax: (210) 567-1719
Cell Phone:  (210) 240-3038
Office Room:  NS 2.644
Office Hours:  Mon 1:00-3:00pm and Thu 1:00-2:00pm
Health Restoration and Care Systems Management Nursing Care Department


In this course students focus on advanced pathophysiological processes across the lifespan, incorporating use of clinical reasoning skills to distinguish alterations across multiple physiological systems.


Credit Hour Allocation: 3 Semester Credit Hours
Clock Hour Allocation: 3 Clock Hours Class (45 hours class)


Graduate standing


Upon completion of the Master of Science in Nursing Program (MSN) students will:

  1. Integrate scientific findings from nursing and related sciences, including genetics and genomics, into the delivery of advanced nursing care to populations in diverse settings.
  2. Demonstrate organizational and systems leadership to assure ethical and critical decision-making at all systems’ levels for quality and patient safety.
  3. Incorporate performance improvement strategies for quality, safety, and patient-centered care delivery.
  4. Use improvement science to achieve optimal patient care and care environment outcomes.
  5. Integrate meaningful and usable information systems and healthcare technologies to support safe, quality patient care and healthcare systems effectiveness.
  6. Advocate for policy changes that influence healthcare at appropriate levels.
  7. Lead interprofessional teams using collaborative strategies to effect quality patient care and population health outcomes.
  8. Analyze and incorporate broad ecological and social health determinants to design and deliver evidence-based clinical prevention and population healthcare and services to individuals, families, and aggregates/identified populations.
  9. Integrate the advanced competencies expected of a master’s prepared nurse to design, deliver, and evaluate outcomes of systems of care for individuals, families, and diverse populations.


Course Objectives
1.  Analyze epigenomics, physiological alterations and pathophysiological processes of disorders and diseases as manifested across the lifespan. (Essentials I, IV, VIII, IX)
2.  Integrate current scientific findings into problem-based analysis of disorders and disease manifested across the lifespan. (Essentials I, III, IV, VIII)
3.  Differentiate among diagnostic studies that evaluate and discriminate pathophysiological processes. (Essentials I, IV, VIII, IX)
4.  Apply clinical reasoning skills and knowledge of pathophysiological processes to advanced nursing practice. (Essentials I, III, IV, VIII, IX)




A = 4 points (90-100)
B = 3 points (80-89)
C = 2 points (75-79)
D = 1 point (66-74)
F = 0 points (65 or below)


Grade Percentages:
20% - Case Study Paper 
20% - Case Study Presentation 
15% - Assigned Group Activities
10% - Module Exam
20% - Quizzes
15% - Final Exam 
100% - Total

Grading Scale:
A = 90-100%
B = 80-89%
C = 70-79%
D = 60-69%
F = Below 60%


Attendance in class is an expectation of each student.


  1. If written assignments are made in a course they are required.
  2. Students are expected to submit written work on the scheduled date and time.
  3. The student must notify the course coordinator prior to the scheduled due date and time if they are unable to submit the written work as scheduled. Failure to make this notification in advance will result in a "zero" for that written work.
  4. If the excuse is accepted as reasonable and necessary, arrangements will be made for an alternative due date and time.
  5. Each student is responsible for making sure that he or she has completed the written work prior to submission.
  6. Late work will be accepted with consequences as outlined per course syllabi.


The APA Publication Manual 6th edition is required for use in all nursing school programs. 


Students are expected to be above reproach in all scholastic activities. Students who engage in scholastic dishonesty are subject to disciplinary penalties, including the possibility of failure in the course and dismissal from the university. "Scholastic dishonesty includes but is not limited to cheating, plagiarism, collusion, and submission for credit of any work or materials that are attributable in whole or in part to another person, taking an examination for another person, any act designed to give unfair advantage to a student or the attempt to commit such acts." Regents Rules and Regulations, Part One, Chapter VI, Section 3, Subsection 3.2, Subdivision 3.22.

School of Nursing Netiquette Guidelines for Online Interaction

Netiquette guidelines provide information for behaving properly online, when using email, tweets or texts so that you may successfully communicate your thoughts in a manner that is respectful and avoids misunderstandings with others.


Any student seeking reasonable accommodations through the Americans with Disabilities Act (ADA) should contact either the Associate Dean for Admissions and Student Services within the first week of the semester or schedule a meeting with the UTHSCSA ADA Compliance Office so that appropriate accommodations may be arranged. A request for accommodations (Form ADA-100: http://uthscsa.edu/eeo/form100-Faculty-student-resident.pdf) must be completed and submitted to the Executive Director of the ADA Compliance Office before accommodations can be provided. Additional information can be provided in the Student Success Center, Room 1.118 or through the ADA Compliance Office website: http://uthscsa.edu/eeo/request.asp.


V. Kumar, A. Abbas, & N. Fausto. (2010). Robbins and Cotran Pathologic Basis of Disease. (8th Ed). Philadelphia:  Elsevier Saunders.  IBSN 978-1-4160-3121-5

R. Mitchell, V. Kumar & N. Fausto. (2006).  Pocket Companion to Robbins and Cotran Pathologic Basis of Disease  (7th Ed.).  Philadelphia:  Elsevier Saunders.  IBSN-13: 9780721602653  
B. J. Sadock & V.A. Sadock. (2007). Kaplan and Sadock’s Synopsis of Psychiatry. (10th Ed). Philadelphia:  Lippincott, Williams & Wilkins.  IBSN-13: 978-0-7817-7327-0  and IBSN-10: 0-7817-7327-X


Current graduate level advanced physiology textbook.

J. Bolte, Taylor (2008).  My Stroke of Insight.  Penguin Group:  USA.  ISBN-13: 9780670020744 and ISBN: 0670020745


Introduction to clinical reasoning in advanced nursing roles

  1. Cellular injury, adaptation and death
    1. Genetic alterations and disorders
    2. Cancer and metastasis
    3. Environmental and nutritional factors
  2. Inflammation, infection, and altered immunity states
    1. Common bacterial, viral, and fungal infections
    2. Altered immune states
      1. Hypersensitivity reactions
      2. Immune deficiency disorders – HIV/AIDS
      3. Common autoimmune disorders
  3. Alterations in integument
    1. Impaired wound healing
    2. Inflammatory and autoimmune
  4. Alterations in hematological function
    1. RBC disorders – anemias
    2. Common bleeding and clotting disorders
    3. Disseminated intravascular coagulation
    4. WBC disorders
      1. Leukemias
      2. Lymphomas
  5. Alterations of neurologic function
    1. Neurotrauma
    2. Seizure disorders
    3. Cerebrovascular disease - stroke
    4. Common degenerative diseases
      1. Alzheimer’s disease
      2. Parkinson’s disease
      3. Dementia
    5. Common infectious disorders
      1. Meningitis
      2. Encephalitis
    6. Myasthenia Gravis
    7. Neurobiology of mental illnesses
      1. Mood disorders
      2. Schizophrenia
  6. Alterations in endocrine function
    1. Diabetes mellitus
    2. Thyroid and parathyroid disorders
    3. Hypothalamic/Pituitary disorders
    4. Adrenal disorders – cortical and medullary
    5. Metabolic Syndrome
  7. Alterations in reproductive function
    1. Common reproductive disorders
    2. Reproductive cancers
    3. Prostate and testicular disorders
    4. Common infectious diseases
  8. Alterations in cardiovascular function
    1. Atherosclerosis/arteriosclerosis
    2. Hypertension
    3. Ischemic heart disease
    4. Valvular heart disorders
    5. Common cardiomyopathies
    6. Heart failure
    7. Common congenital disorders
    8. Peripheral vascular diseases
      1. Venous disease
      2. Arterial disease
      3. Aneurysms
  9. Alterations in pulmonary function
    1. Pulmonary edema
    2. Obstructive disease
      1. Emphysema
      2. Chronic Bronchitis
      3. Asthma
    3. Restrictive disease
      1. Pulmonary fibrosis
    4. Common pulmonary infections
    5. Lung cancer
  10. Alterations in uro-renal function
    1. Common infectious states
    2. Obstructive disorders
    3. Glomerulonephritis
    4. Nephritic vs. nephritic syndromes
    5. Renal failure
      1. Acute
      2. Chronic
  11. Alterations in gastrointestinal function
    1. Common esophageal and gastric disorders
    2. Common infectious disorders
    3. Inflammatory bowel disorder
    4. Malignancies
  12. Alterations in hepatic, biliary, and pancreatic function
    1. Hepatitis
    2. Cirrhosis
    3. Cholelithiasis and cholecystitis
    4. Pancreatitis
  13. Alterations in musculoskeletal function
    1. Traumatic disorders of bone and joints
    2. Infectious state –osteomyelitis
    3. Osteoporosis
    4. Arthritic disorders
      1. Osteoarthritis
      2. Rheumatoid arthritis
    5. Myositis disorders
    6. Muscular dystrophy
    7. Rhabdomyolysis
  14. Multiple Organ Dysfunction Syndrome and Shock
    1. Cardiopulmonary
    2. Septic
    3. Multiple trauma
    4. Burns

CALENDAR - 1st Day Only

Please check the schedule for recent updates on Class Dates & Room.

Topic / Assignment Due: 
During the first week of class, you will take a pre-course Knowledge Assessment Quiz covering normal physiology.  If you need a review of normal anatomy and physiology prior to the Knowledge Assessment Quiz, you may want to visit the following sites or search for others:   




© School of Nursing | The University of Texas Health Science Center at San Antonio external link
Links provided from Health Science Center School of Nursing pages to other websites do not constitute or imply an endorsement of those sites, their content, or products and services associated with those sites.

School of Nursing - UT Health Science Center San Antonio