Spring 2018

NURS 5338-001 Advanced Pathophysiology

All students are responsible for checking their UTHSCSA Livemail account regularly (i.e., daily or several times every week) to obtain Official University Communication regarding their courses, program and student status.

NOTE: Our campus has enabled the CANVAS MOBILE LEARN application. CANVAS tools such as discussions, quizzes or videos May or May NOT function on all mobile devices. This is because mobile devices are available with rapidly changing and different configurations. Hence, students must not depend on only a mobile device to access course materials. Students must have access to a laptop or desktop device to access course materials and complete assignments.

This course is Web Enhanced with WebCT icon
Please be sure to check the Current Computer Requirements

Welcome to NURS 5338: Advanced Pathophysiology.  The first meeting date
will be Wednesday, January 10, 2018 in the ALTC room 2.202
All course information and class content will be available on Canvas. If you have any questions, please do not hesitate to contact me at (210) 567-5310.


Nancy McGowan, RN, PhD, CEN
Email:  McGowann@uthscsa.edu
Office phone:  (210) 567-5310
Office : 2.222


In this course students focus on advanced pathophysiological processes across the lifespan, incorporating use of clinical reasoning skills to distinguish alterations across multiple physiological systems.


Credit Hour Allocation: 3 Semester Credit Hours
Clock Hour Allocation: 3 Clock Hours Class (45 hours class)


Graduate standing


Upon completion of the Master of Science in Nursing Program (MSN) students will:

  1. Integrate scientific findings from nursing and related sciences, including genetics and genomics, into the delivery of advanced nursing care to populations in diverse settings.
  2. Demonstrate organizational and systems leadership to assure ethical and critical decision-making at all systems’ levels for quality and patient safety.
  3. Incorporate performance improvement strategies for quality, safety, and patient-centered care delivery.
  4. Use improvement science to achieve optimal patient care and care environment outcomes.
  5. Integrate meaningful and usable information systems and healthcare technologies to support safe, quality patient care and healthcare systems effectiveness.
  6. Advocate for policy changes that influence healthcare at appropriate levels.
  7. Lead interprofessional teams using collaborative strategies to effect quality patient care and population health outcomes.
  8. Analyze and incorporate broad ecological and social health determinants to design and deliver evidence-based clinical prevention and population healthcare and services to individuals, families, and aggregates/identified populations.
  9. Integrate the advanced competencies expected of a master’s prepared nurse to design, deliver, and evaluate outcomes of systems of care for individuals, families, and diverse populations.


Course Objectives
1.  Analyze epigenomics, physiological alterations and pathophysiological processes of disorders and diseases as manifested across the lifespan. (Essentials I, IV, VIII, IX)
2.  Integrate current scientific findings into problem-based analysis of disorders and disease manifested across the lifespan. (Essentials I, III, IV, VIII)
3.  Differentiate among diagnostic studies that evaluate and discriminate pathophysiological processes. (Essentials I, IV, VIII, IX)
4.  Apply clinical reasoning skills and knowledge of pathophysiological processes to advanced nursing practice. (Essentials I, III, IV, VIII, IX)




A = 4 points (90-100)
B = 3 points (80-89)
C = 2 points (75-79)
D = 1 point (66-74)
F = 0 points (65 or below)


Grade Percentages:
50% - Assigned Activities
         Includes: group discussions, in-class activities, others
50% - Exams/Quizzes
100% - Total

This course is not based on weighted grades.  Each student's grade is based on the points achieved by the student during the semester.

Grading Scale (per points achieved):
A = 90-100% (900-1000 points)
B = 80-89%  (800-899 points)
C = 70-79% (700-799 points)
D = 60-69% (600-699 points)
F = Below 60% (Below 600 points)


Attendance in class is an expectation of each student.


  1. If written assignments are made in a course they are required.
  2. Students are expected to submit written work on the scheduled date and time.
  3. The student must notify the course coordinator prior to the scheduled due date and time if they are unable to submit the written work as scheduled. Failure to make this notification in advance will result in a "zero" for that written work.
  4. If the excuse is accepted as reasonable and necessary, arrangements will be made for an alternative due date and time.
  5. Each student is responsible for making sure that he or she has completed the written work prior to submission.
  6. Late work will be accepted with consequences as outlined per course syllabi.


The APA Publication Manual 6th edition is required for use in all nursing school programs. 


Students are expected to be above reproach in all scholastic activities. Students who engage in scholastic dishonesty are subject to disciplinary penalties, including the possibility of failure in the course and dismissal from the university. "Scholastic dishonesty includes but is not limited to cheating, plagiarism, collusion, and submission for credit of any work or materials that are attributable in whole or in part to another person, taking an examination for another person, any act designed to give unfair advantage to a student or the attempt to commit such acts." Regents Rules and Regulations, Part One, Chapter VI, Section 3, Subsection 3.2, Subdivision 3.22.


Students who are nurses or are preparing to enter the profession of nursing are expected to treat others with respect and compassion. “The principle of respect for persons extends to all individuals with whom the nurse interacts. The nurse maintains compassionate and caring relationships with colleagues and others with a commitment to the fair treatment of individuals, to integrity-preserving compromise and to resolving conflict. This standard of conduct precludes any and all prejudicial actions, any form of harassment or threatening behavior, or disregard for the effects of one’s actions on others” (American Nurses Association Code for Nurses, Interpretive Statement 1.5).

The students, faculty, Department Chairs, Associate Deans, and the Dean of the School of Nursing of the University Texas Health Science Center San Antonio subscribe to the highest standards of conduct. Our aim is professional behavior beyond reproach. Failure to abide by the signed code of professional conduct may lead to suspension and/or permanent dismissal from the UTHSCSA SON. In particular, we subscribe to the provisions of the Code of Ethics for Nurses (http://bit.ly/1mtD5p2) and the following points of conduct.


School of Nursing Netiquette Guidelines for Online Interaction

Netiquette guidelines provide information for behaving properly online, when using email, tweets or texts so that you may successfully communicate your thoughts in a manner that is respectful and avoids misunderstandings with others.


Any student seeking reasonable accommodations through the Americans with Disabilities Act (ADA) should contact either the Associate Dean for Admissions and Student Services within the first week of the semester or schedule a meeting with the UTHSCSA ADA Compliance Office so that appropriate accommodations may be arranged. A request for accommodations (Form ADA-100: http://uthscsa.edu/eeo/form100-Faculty-student-resident.pdf) must be completed and submitted to the Executive Director of the ADA Compliance Office before accommodations can be provided. Additional information can be provided in the Student Success Center, Room 1.118 or through the ADA Compliance Office website: http://uthscsa.edu/eeo/request.asp.


V. Kumar, A. Abbas, & J. Aster. (2015). Robbins and Cotran Pathologic Basis of Disease. (9th Ed). Philadelphia:  Elsevier Saunders.  IBSN 978-1-4557-2613-4

R. Mitchell, V. Kumar, A. Abbas, N. Fausto & J. Aster (2016).  Pocket Companion to Robbins and Cotran Pathologic Basis of Disease  (9th Ed.).  Philadelphia:  Elsevier Saunders.  IBSN


Taylor, J.B. (2008).  My stroke of insight.  Penguin Group:  USA.  ISBN-13: 9780670020744 and ISBN: 0670020745


Advancedpathophysiology across the life span is analyzed in the following processes:

1.            Cellular and epigenomic alterations, adaptation, malignancy anddeath

2.            Immune function alterations

3.            Integument and tissue repair alterations

4.            Hematological function alterations

5.            Neurologic function alterations

6.            Endocrine function alterations

7.            Reproductive function alterations

8.            Cardiovascular function alterations

9.            Pulmonary function alterations

10.        Renal function alterations

11.        Gastrointestinal tract and related body systems functionalterations

12.        Musculoskeletal function alterations

13.        Multi-system function alterations

CALENDAR - 1st Day Only

Please check the schedule for recent updates on Class Dates & Room.

Prep for first day of class - review the documents that provide an overview of the course, located on CANVAS, under COURSE CONTENT section, then open COURSE INFORMATION. 

Also look for the COURSE SCHEDULE in this section. It will give details of the scheduled topics, readings, and assignments for the first day and course.

Prior to the first day of class, you need to complete two documents:

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